Key Factor Study for Generic Long-Acting PLGA
Vivitrol ® is a PLGA microsphere product that encapsulates and slowly releases naltrexone (NTX) and is one of the only two approved small molecular drugs loaded with PLGA microspheres (alongside Risperdal Consta ®).It can maintain stable and pharmacologically relevant plasma concentrations of NTX for at least 30 days. Vivitrol ® was approved by the FDA for the treatment of alcohol
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In Vitro and In Vivo Evaluations of PLGA Microspheres
· Poly (lactic-co-glycolic acid) (PLGA) the US Food and Drug Administration (FDA) approved biodegradable polymer for in vivo use is now employed in several parenteral microspheres in the market (e.g. Zoladex Trelstar Vivitrol Lupron Depot and Risperdal Consta).
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Key Factor Study for Generic Long-Acting PLGA
Vivitrol ® is a PLGA microsphere product that encapsulates and slowly releases naltrexone (NTX) and is one of the only two approved small molecular drugs loaded with PLGA microspheres (alongside Risperdal Consta ®).It can maintain stable and pharmacologically relevant plasma concentrations of NTX for at least 30 days. Vivitrol ® was approved by the FDA for the treatment of alcohol
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Preparation and in vitro/in vivo evaluation of PLGA
· Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection Chun-Woong Park 1 Hyo-Jung Lee 1 Dong-Won Oh 1 Ji-Hyun Kang 1 Chang-Soo Han 1 Dong-Wook Kim21College of Pharmacy Chungbuk National University Cheongju Republic of Korea 2Department of Pharmaceutical Engineering Cheongju University Cheongju Republic of
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PLGA MICROPARTICLES SYNTHESISFluigent
· PLGA/PLA microparticles can be used to encapsulate hydrophobic as hydrophilic thera-peutics drugs and allowing for reduced dosing frequency and less potential toxicity. 9–11 In PLGA microparticle production for drug release and delivery micropar-ticle size is a paramount parameter. Indeed the microparticle size is directly re-
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Engineered PLGA microspheres for extended release of
· A PLGA microsphere loaded with brexpiprazole was successfully developed and demonstrated potential for extended-release of therapeutics for schizophrenia treatment. Full text links . Read article at publisher s site (DOI) 10.1080/.2021.. Similar Articles .
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Injectable PLGA microsphere/calcium phosphate cements
· PLGA microspheres were prepared using a water-in-oil-in-water double-emulsion technique. The CaP-cement used was Calcibon ® a commercially available hydroxyapatite-based cement. 10 90 and 20 80 dry wt PLGA microsphere/CaP cylindrical scaffolds were prepared as well as microporous cement (reference material). Injectability setting time
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Release of a Wound-Healing Agent from PLGA Microspheres
The purpose of this research was to develop a topical microsphere delivery system in a thermosensitive 20 poloxamer 407 gel (Pluronic F127) to control release of KSL-W a cationic antimicrobial decapeptide for a period of 4–7 days for potential application in combat related injuries. KSL-W loaded microsphere formulations were prepared by a solvent extraction-evaporation method (water-oil
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Design of Controlled Release PLGA Microspheres for
· The most optimal microsphere formulation with 20 Brij 98 as excipient showed an initial in vitro burst around 20 and a sustained release over 28 days in a solubilizing release medium at 37 °C. The effect of addition of MgCO3 drug loading and polymer blending on the release of fenretinide from PLGA microspheres was also investigated and
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Engineered PLGA microspheres for extended release of
· A PLGA microsphere loaded with brexpiprazole was successfully developed and demonstrated potential for extended-release of therapeutics for schizophrenia treatment. Full text links . Read article at publisher s site (DOI) 10.1080/.2021.. Similar Articles .
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Pre-vascularization in fibrin Gel/PLGA microsphere
· The fibrin precursor solution (fibrinogen) containing cells was mixed with the PLGA microsphere scaffold and coagulated in situ. The two components
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Preparation and in vitro/in vivo evaluation of PLGA
· Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection Chun-Woong Park 1 Hyo-Jung Lee 1 Dong-Won Oh 1 Ji-Hyun Kang 1 Chang-Soo Han 1 Dong-Wook Kim21College of Pharmacy Chungbuk National University Cheongju Republic of Korea 2Department of Pharmaceutical Engineering Cheongju University Cheongju Republic of
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Pre-vascularization in fibrin Gel/PLGA microsphere
· The fibrin precursor solution (fibrinogen) containing cells was mixed with the PLGA microsphere scaffold and coagulated in situ. The two components
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Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable
· PLGA micro/nanoparticles have also been used for multiple applications in a single formulation. PLGA particles may be used to encapsulate absorption and fluorescence dyes in addition to a drug for multimodal imaging using fluorescence (FL) ultrasound (US) or
Get PriceRelease of a Wound-Healing Agent from PLGA Microspheres
The purpose of this research was to develop a topical microsphere delivery system in a thermosensitive 20 poloxamer 407 gel (Pluronic F127) to control release of KSL-W a cationic antimicrobial decapeptide for a period of 4–7 days for potential application in combat related injuries. KSL-W loaded microsphere formulations were prepared by a solvent extraction-evaporation method (water-oil
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Recent research and development of PLGA/PLA
The oil phase containing PLGA is pumped through a small inner nozzle to form a smooth cylindrical jet. The jet is acoustically excited to break the oil phase into uniform droplets under preset conditions. To control the microsphere size an external phase flows concentrically around the inner jet
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Key Factor Study for Generic Long-Acting PLGA
· Vivitrol®is a PLGA microsphere product that encapsulates and slowly releases naltrex- one (NTX) and is one of the only two approved small molecular drugs loaded with PLGA microspheres (alongside Risperdal Consta®). It can maintain stable and pharmacologically
Get Price
Mathematical modeling of drug delivery from
· PLGA is a bulk-eroding polymer at the length scales used in drug delivery microspheres (10s to 100s of microns) as the hydration time scale is on the order of a few minutes compared to weeks or months for degradation 24 25 26 . Erosion depends
Get PriceSeeing is believing PLGA microsphere degradation
· The PLGA microsphere/PVA hydrogel composites were prepared using a previously developed freeze–thaw method 28 . Different amounts of PLGA microspheres (0 50 75 and 100 mg) were dispersed in 1 mL 5 (w/w) PVA solutions (133 kDa) and the dispersions were filled into 1-mLsyringes (BDprecision glide). Threefreeze–thaw cycles
Get PricePLGA Microsphere Addition to 1‐Hydroxy‐2‐napthoic Acid
· PLGA Microsphere Addition to 1-Hydroxy-2-napthoic Acid Enhances the Sustained Release of Escitalopram. Correction(s) for this article. Seok Hee Kang Bio/Drug Discovery Division Korea Research Institute of Chemical Technology Daejeon South Korea. Medicinal Chemistry and Pharmacology University of Science and Technology Yuseong 305
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Recent research and development of PLGA/PLA
The culture period is 7 d. (A1) Original nonporous PLGA microsphere (B1) original porous PLGA microspheres (A2) collagen I coated nonporous PLGA microspheres (B2) collagen I coated porous PLGA microspheres (reprinted from 36 copyright (2014) with permission from Elsevier)
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Preliminary evaluates of silica/β-TCP/PLGA microspheres
· cium phosphate (β-TCP)/PLGA microspheres coated with silica nanoparticles may be beneficial for the growth and differentiation of hDPCs and is a potential scaffold material for dentin regeneration. Accordingly this study was intended to prepare a silica/β-TCP/PLGA
Get PriceJournal of Controlled ReleaseMIT
· PLGA microspheres are widely studied for controlled release drug delivery applications and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Au-tocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead
Get PricePLGA Microspheres Containing Hydrophobically Modified
· Poly (lactic-co-glycolic acid) (PLGA) microspheres have been actively used in various pharmaceutical formulations because they can sustain active pharmaceutical ingredient release and are easy to administer into the body using a syringe.
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Journal of Controlled ReleaseMIT
· PLGA microspheres are widely studied for controlled release drug delivery applications and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Au-tocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead
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Drug-encapsulated blend of PLGA-PEG microspheres in vitro
· Finally the Trypan blue dye (TBD) cell count was used to confirm the effects of the drug-loaded PLGA-PEG microsphere treatment on MDA--231 cell viability. An
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Microencapsulation by solvent extraction/evaporation
· produced microsphere mean diameters decreasing from 38 to 14 Am with impeller speed increasing segmentially from 250 to 1600 rpm using PLGA dissolved in DCM and an aqueous hydroxypropylme-thylcellulose (HPMC) solution as disperse and con-
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PLGA MicrospheresFlexion Therapeuticsfor musculoskeletal conditions. PLGA.
Get PriceBiodegradable calcium carbonate/mesoporous silica/poly
Injectable microsphere-based scaffolds such as PLGA-based scaffolds are liquid suspensions that can obtain the shape of defects after implantation. 10 11 They may be easy to migrate from the defect sites after implantation due to weak interparticle interactions. 8 However the sintered microsphere-based scaffolds are made into a specific
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